Scientists have determined that the remedy for diarrhea can fight brain cancer
The fight against cancer is conducted by scientists around the world for centuries, but only relatively recently begun to receive some encouraging news. However, as usual, open hidden in the banal, familiar all things. Two years ago, German doctors determined that the remedy for bowel disorders loperamide, familiar to generations of humans, destroys cancer cells in cell lines, the glioblastoma — one of the most dangerous malignant tumors of the brain.
But the detection of effect until it can be called a discovery, is a long time. Researchers from Goethe University in Frankfurt am main, it took two years to explain how it can influence the drug from diahrea on the cells of cancerous tissue.
Of all malignant tumors of the brain, the glioblastoma is the most aggressive and intractable. An important feature of this cancer is its weak sensitivity to the action of drugs used in chemotherapy. That's why the best minds of the scientific world are working on developing drugs for the treatment of glioblastoma.
It is difficult to say why the scientists from Frankfurt decided to try the remedy of diarrhea in cancer cells, but they were not full, but tangible success. Introduction loperamide leads to stress response in endoplasmic reticulum (ER) of cancer cells, unfortunately, not all in a row. This stress causes disturbances in nutrition of the cancer cell, its degradation and destruction.
The UK stress causes high activity of ATF4 protein, which is the one most familiar to each of us loperamide. While scientists already were convinced that the drug acts selectively and does not pose a threat to healthy cells of the body. This is a very important discovery, which though cannot be called a victory against glioblastoma, but it can be described as one of the most effective ways on the way.
It looks like a molecular model loperamide
this is not the first strange and important discovery this winter. Earlier, scientists from New Zealand said that he had learned to treat diabetes and heart disease capsules in the faeces.
Keywords: Disease | Germany | The researchers | Treatment | Surprise | Oncology | Cancer | Frankfurt